Optical Coherence Tomography for Quantitative Diagnosis in Nasopharyngeal carcinoma

Jianghua Li


We tried to quantitative diagnosis the intrinsic differences in the optical properties of nasopharyngeal carcinoma (NPC) from normal tissue by OCT. The scattering coefficients and anisotropies are extracted by fitting the average a-scan attenuation curves based on the multiple scatter effect. The median scattering coefficients of epithelium are 2.2 mm−1 (IQR 1.5 to 2.5 mm−1) for normal versus 3.8 mm−1 (IQR 2.0 to 3.3 mm−1) for cancer tissue; of lamina propria are 2.9 mm−1 (IQR 1.5 to 2.5 mm−1) for normal versus 1.3 mm−1 (IQR 1.2 to 12 mm−1) for cancer tissue; and anisotropy factors of epithelium are 0.91 (IQR 0.9 to 0.93) versus 0.91 (IQR 0.88 to 0.97) for normal and cancer tissue; of lamina propria are 0.98 (IQR 0.94 to 0.99) for normal versus 0.98 (IQR 0.96 to 0.99) for cancer, respectively. The results show quantitative values of scattering coefficients combing with the morphological by OCT can improve the diagnosis rate of NPC.

Full Text:

PDF Citation


Wei KR, Zheng RS, Zhang SW, et al. Nasopharyngeal carcinoma incidence and mortality in China in 2010[J]. Chin J Cancer, 2014, 33(8): 381–387.

Ho FC, Tham IW, Earnest A, et al. Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence[J]. BMC Cancer, 2012, 12: 98.

Wei WI, Sham JS. Nasopharyngeal carcinoma[J]. Lancet, 2005, 365(9476): 2041–2054.

Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography[J]. Science, 1991, 254(5035): 1178–1181.

Raghunathan R, Singh M, Dickinson ME, et al. Optical coherence tomography for embryonic imaging: a review[J]. J Biomed Opt, 2016, 21(5): 50902.

Mogensen M, Thrane L, Jørgensen TM, et al. OCT imaging of skin cancer and other dermatological diseases[J]. J Biophotonics, 2009, 2(6–7): 442–451.

Fujimoto JG. Optical coherence tomography for ultrahigh resolution in vivo imaging[J]. Nat Biotechnol, 2003, 21(11): 1361–1367.

Pan Y, Lavelle JP, Bastacky SI, et al. Detection of tumorigenesis in rat bladders with optical coherence tomography[J]. Med Phys, 2001, 28(12): 2432–2440.

Qi X, Sivak MV, Isenberg G, et al. Computer-aided diagnosis of dysplasia in Barrett's esophagus using endoscopic optical coherence tomography[J]. J Biomed Opt, 2006, 11(4): 044010.

Goldberg BD, Iftimia NV, Bressner JE, et al. Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidance[J]. J Biomed Opt, 2008, 13(1): 014014.

Zakharov V P, Bratchenko I A, Myakinin O O, et al. Multimodal diagnosis and visualisation of oncologic pathologies[J]. Quantum Electronics, 2014, 44(8): 726–731.

Levitz D, Thrane L, Frosz M, et al. Determination of optical scattering properties of highly-scattering media in optical coherence tomography images[J]. Opt Express, 2004, 12(2): 249–259.

Thrane L, Yura HT, Andersen PE. Analysis of optical coherence tomography systems based on the extended Huygens-Fresnel principle[J]. J Opt Soc Am A Opt Image Sci Vis, 2000, 17(3): 484–490.

Wang K, Ding Z, Wang L. Determining tissue optical properties by optical coherence tomography[J]. Acta Photonica Sinica, 2008, 6534(3):65340F–65340F–10.

Wang K, Ding ZH, Wang L, Wang K, Ding ZH, Wang L, Measuring Tissue Optical Properties by Optical Coherence Tomography[J]. Acta Photonica Sinica, 2008, 37(3): 523–527.

Qu J, Macaulay C, Lam S, et al. Optical properties of normal and carcinomatous bronchial tissue[J]. Appl Opt, 1994, 33(31): 7397–7405.

Liu L, Gardecki JA, Nadkarni SK, et al. Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography[J]. Nat Med, 2011, 17(8): 1010–1014.

Pan sh ch. Hunan College of Medicine Cancer Research Centre Nasopharyngeal carcinoma cytological map. 1981 People's Health Press, Beijing, 87–88

Wessels R, De Bruin DM, Faber DJ, et al. Optical biopsy of epithelial cancers by optical coherence tomography (OCT)[J]. Lasers Med Sci, 2014, 29(3): 1297–1305.

van Leeuwen T G, Faber D J, Aalders M C. Measurement of the axial point spread function in scattering media using single-mode fiber-based optical coherence tomography[J]. IEEE Journal of Selected Topics in Quantum Electronics, 2003, 9(2): 227–233.

Faber D J, van der Meer F J, Aalders M C G, et al. Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography[J]. Optics Express, 2004, 12(19): 4353.

DOI: http://dx.doi.org/10.15383/jnpc.40


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

eISSN: 2312-0398

Asia Press is a professional Science, Technology and Medicine publisher, who owns rapid publication, Peer-Reviewed, Open Access Journals. Asia Press aims to promote “knowledge sharing”. As you know, the main barrier for free “knowledge sharing” is the cost of publishing and transfer. In order to encourage scholars and scientists to the max, and devote whole power to realize the aim of “knowledge sharing” and the benefit of “all” mankind, Asia Press performs a permanent policy of no charge for publication and access, and always open its door for authors worldwide.

© 2013-2017 by the Asia Press. All rights reserved.