Genetic association on radiation induced mucosal and skin toxicity in patients with nasopharyngeal carcinoma
Radiation therapy (RT) is the primary treatment for many head and neck cancers including nasopharyngeal carcinoma (NPC). While prognosis has been greatly improved with the advancement of RT technique, radiation-induced complications especially normal tissue surrounding tumour volume is unavoidable. Genetic factors are thought to be the most important factors contributing to individual variation in radiation sensitivity. Over 120 studies have been published since year 2000 to investigate the association of genetic variants to radiation-induced toxicities in various types of cancer. Candidate gene approach is the most commonly used approach in published studies, including studies in patients with NPC. Skin and mucosal toxicities are two of the most common radiation induced complications in the radiotherapy of NPC patients. However, studies focused on radiation toxicity in NPC patients are limited. Published literatures focused on genetic variations and radiation sensitivity in NPC patients are summarized in this review, and recommendations for future studies are also suggested.
Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet 2005;365:2041-2054.
Ng WT, Lee MC, Hung WM et al. Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2011;79:420-428.
Wei WI, Kwong DL. Current management strategy of nasopharyngeal carcinoma. Clinical and experimental otorhinolaryngology 2010;3:1-12.
Kam MK, Chau RM, Suen J, Choi PH, Teo PM. Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys 2003;56:145-157.
Peng G, Wang T, Yang KY et al. A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol 2012;104:286-293.
Pow EH, Kwong DL, McMillan AS et al. Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 2006;66:981-991.
Lee AW, Lau WH, Tung SY et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol 2005;23:6966-6975.
Lee AW, Tung SY, Chua DT et al. Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 2010;102:1188-1198.
Wells M, MacBride S. Radiation skin reactions. In: Faithfull S and Wells M, eds. Supportive care in radiotherapy, 2003; 135-159.
Westbury CB, Yarnold JR. Radiation fibrosis--current clinical and therapeutic perspectives. Clinical oncology 2012;24:657-672.
Azria D, Betz M, Bourgier C, Jeanneret Sozzi W, Ozsahin M. Identifying patients at risk for late radiation-induced toxicity. Critical reviews in oncology/hematology 2012;84 Suppl 1:e35-41.
Barnett GC, West CM, Dunning AM et al. Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat Rev Cancer 2009;9:134-142.
Borgmann K, Roper B, El-Awady R et al. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 2002;64:141-152.
Popanda O, Marquardt JU, Chang-Claude J, Schmezer P. Genetic variation in normal tissue toxicity induced by ionizing radiation. Mutat Res 2009;667:58-69.
Gatti RA. The inherited basis of human radiosensitivity. Acta Oncol 2001;40:702-711.
Faulhaber O, Bristow R. Basis of cell kill following clinical radiotherapy. Application of apoptosis to cancer treatment 2005:293-320.
Kiang JG, Garrison BR, Gorbunov NV. Radiation combined injury: DNA damage, apoptosis, and autophagy 2010;2:1-10.
Bentzen SM. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer 2006;6:702-713.
Tabor HK, Risch NJ, Myers RM. Candidate-gene approaches for studying complex genetic traits: practical considerations. Nature reviews. Genetics 2002;3:391-397.
McCarthy MI, Abecasis GR, Cardon LR et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature reviews. Genetics 2008;9:356-369.
Alsbeih G, El-Sebaie M, Al-Harbi N et al. SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers. Radiat Oncol 2013;8:125.
Li HJ, You YJ, Lin CF et al. XRCC1 codon 399Gln polymorphism is associated with radiotherapy-induced acute dermatitis and mucositis in nasopharyngeal carcinoma patients. Radiat Oncol 2013;8.
Alsbeih G, Al-Harbi N, Al-Hadyan K, El-Sebaie M, Al-Rajhi N. Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes. Radiat Res 2010;173:505-511.
Alsbeih GA, El-Sebaie MM, Al-Rajhi NM et al. Association between XRCC1 G399A polymorphism and late complications to radiotherapy in Saudi head and neck cancer patients. J Egypt Natl Canc Inst 2008;20:302-308.
Kornguth DG, Garden AS, Zheng Y et al. Gastrostomy in oropharyngeal cancer patients with ERCC4 (XPF) germline variants. Int J Radiat Oncol Biol Phys 2005;62:665-671.
Lundberg M, Saarilahti K, Makitie AA, Mattila PS. TGFbeta1 genetic polymorphism is associated with survival in head and neck squamous cell carcinoma independent of the severity of chemoradiotherapy induced mucositis. Oral Oncol 2010;46:369-372.
Pratesi N, Mangoni M, Mancini I et al. Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer. Radiother Oncol 2011;99:356-361.
Werbrouck J, De Ruyck K, Duprez F et al. Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes. Int J Radiat Oncol Biol Phys 2009;73:1187-1195.
Barnett GC, Coles CE, Elliott RM et al. Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study. Lancet Oncol 2012;13:65-77.
Talbot CJ, Tanteles GA, Barnett GC et al. A replicated association between polymorphisms near TNFalpha and risk for adverse reactions to radiotherapy. Br J Cancer 2012;107:748-753.
Pang Q, Wei Q, Xu T et al. Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer. Int J Radiat Oncol Biol Phys 2013;85:1332-1339.
Kerns SL, Ostrer H, Stock R et al. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2010;78:1292-1300.
Kerns SL, Stock R, Stone N et al. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of erectile dysfunction following radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 2013;85:e21-28.
Barnett GC, Elliott RM, Alsner J et al. Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. Radiother Oncol 2012;105:289-295.
Zhu M-L, Wang M, Shi T-Y et al. No Association between TGFB1 Polymorphisms and Late Radiotherapy Toxicity: A Meta-Analysis. PLoS One 2013;8:e76964.
Kerns SL, Ruysscher DD, Andreassen CN et al. STROGAR - STrengthening the Reporting Of Genetic Association studies in Radiogenomics. Radiother Oncol 2013.
West C, Rosenstein BS. Establishment of a radiogenomics consortium. Radiother Oncol 2010;94:117-118.
Little J, Higgins JP, Ioannidis JP et al. STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med 2009;6:e22.
Mayer C, Popanda O, Greve B et al. A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects. Cancer Lett 2011;302:20-28.
Cookson W, Liang L, Abecasis G, Moffatt M, Lathrop M. Mapping complex disease traits with global gene expression. Nature reviews. Genetics 2009;10:184-194.
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