Progress of tumor marker research in Nasopharyngeal carcinoma

Yuan Zhu, Weiguo Huang, Sanyuan Tang


 Nasopharyngeal carcinoma (NPC) is a prevalent tumour in southernChina and southeast Asia, particularly in the Cantonese population, where its incidence has remained high for decades.This cancer is an Epstein-Barr virus-associated malignancy with a remarkable racial and geographical distribution. It is highly prevalent in southern Asia where the disease occurs at a prevalence about a 100-fold higher compared with other populations not at risk. We still see patients recur after primary treatment with radiotherapy or chemo-irradiation. Management of nasopharyngeal carcinoma remains one of the biggest clinical challenges. There have been break throughs in early detection, diagnosis, multi-modality treatment and also disease monitoring for NPC. Systemic treatment has been crucial to the management of locally advanced or metastatic NPC. With the advent of molecular targeted therapy and personalized medicine, novel therapies based on molecular targets of NPC have become the focus of research and development over the last decade,The etiology of NPC is thought to be associated with a complex interaction of genetic, viral,environmental and dietary factors.Thanks to the advancements in genomics, proteomics and bioinformatics in recent decades, more understanding of the disease etiology,carcinogenesis and progression has been gained. Research into these components may unravel the pathways in NPC development and potentially decipher the molecular characteristics of the malignancy in recent years, the attention to the study of tumor markers associated with the NPC, this paper summarizes the research progress of the NPC in recent years, a variety of  related research progress of tumor markers and its early diagnosis and curative effect evaluation to the NPC, treatment and prognosis of great significance.


NPC, Tumor marker

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